Dr. Sharlin's Brain Tune Up Supplements

Neuro-Active B
Neuro-Active B
Neuro-Active B

Neuro-Active B




✅ Aids brain neurotransmitter production
✅ Promotes DNA repair
✅ Supports heart and mind functionality


Methylation is a vitamin-requiring biochemical process in the body that is critical for supporting many aspects of mental and physical health, including regulating gene expression. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis.

When methylation processes in the body slow down, an increase in the breakage of DNA strands can occur.  In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, and recycling of molecules that are required for detoxification and supporting healthy inflammatory response.

Methylation is also required for proper energy metabolism, immune and nerve cell function. Proper methylation can be inhibited by genetic variations in the enzymes that activate key B-vitamins, and this is why Neuro-Active B contains the forms of these vitamins that bypass the enzymes because they are already activated.

Other factors that can interfere with methylation include deficiencies of folate, B2, B6 and B12. Certain medications such as acetaminophen, aspirin, ibuprofen and oral contraceptives can also deplete blood levels of these crucial B vitamins.


Folate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is abundantly found in foods such as fruits and dark leafy vegetables but can be easily destroyed by cooking or processing. The bioactive form of folate is 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is required as a methyl group donor for several processes, including the production of mood regulating neurotransmitters, the synthesis of melatonin, and DNA production and repair.

Vitamin B12
Vitamin B12 works with folate in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. 

Vegetarians and the elderly run the highest risk of B12 deficiency.

Methylcobalamin is the preferred form of B12, as it is the biologically active form of B12 and supports the up-regulation of methylation pathways.

Vitamin B6
Vitamin B6 is a crucial B vitamin that is involved in the production of proteins in the body, neurotransmitters that help regulate mood, red blood cell formation and the proper functioning of the immune system. B6 is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with 5-MTHF and B12 in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining normal blood pressure.

Vitamin B2
Optimizing B2 status helps support healthy blood pressure, particularly in patients with genetic mutations (MTHFR 677 > T polymorphism).

Betaine (Trimethylglycine)
As a methyl donor, trimethylglycine supports liver function, including detoxification pathways. Trimethylglycine has been shown to be beneficial in protecting against fat accumulation in the liver, due to its lipotropic properties (donating a methyl group to aid in the transport of fat out of the liver). Trimethylglycine also works alongside B2, B6, B12 and folate in maintaining normal homocysteine levels.


Those looking to increase brain function and combat any cognitive decline should take Neuro-Active B.
Studies have shown that the body's natural ability to absorb vitamin B decreases as we age.
Neuro-Active B provides your body with the necessary B vitamins. It then leverages your body’s revitalized ability to absorb nutrients with doses of Methylation; this greatly improves your brain's neurotransmitter production, DNA repair, and overall functionality.


Recent studies show a link between poor gut health and poor immunity. When you are sick, your brain doesn't function as well as it normally would. My Brain Biotic supplement helps to improve your overall gut function and keep your brain sharp and your immune system strong. Those who struggle with getting sick or have frequent issues with their digestive system should really consider purchasing my Brain Biotic and taking 1 pill per day.

Please let me know if you have any questions or need help finding a particular supplement. 

What Dr. Sharlin's Patients Have To Say

"I’ve been seeing Dr. Sharlin since the first of this year. We’re extremely pleased with him and his overall concern for my health issues. He’s helped me tremendously in every aspect of my ongoing health problems since my head injury several years ago."
- Debra -

"Dr. Sharlin and his staff genuinely care about their patients!  I’ve had migraines for 28 years and never had a neurologist work so diligently to help me find relief.  I recommend them to everyone!!"
- Amy -

"As always my experience with Sharlin Health and Neurology was great. If you are looking for a caring, knowledgeable and proactive group of professionals, this is the place."
- Kathy -

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Meet Dr. Sharlin

Ken Sharlin, M.D., M.P.H., IFMCP, is a board-certified neurologist, consultant, functional medicine practitioner, Assistant Clinical Professor, researcher, author, and speaker.

His medical degrees are from Emory University, The University of Virginia, and Vanderbilt University.

His functional medicine certification is through The Institute for Functional Medicine.

He is author of the #1 best-seller The Healthy Brain Toolbox: Neurologist-Proven Strategies to Improve Memory Loss and Protect Your Aging Brain and co-author of Neurishment: The Brain Tune Up! Food Guide.

Dr. Sharlin is also a major contributor to Reversal of Cognitive Decline: 100 Patients. This can be found in the peer-reviewed Journal of Alzheimer’s & Parkinsonism, and he has been the primary investigator in several pharma-sponsored clinical trials that have helped bring new therapeutics to market.

Dr. Sharlin practices general neurology and directs his functional medicine program, Brain Tune Up!, in Ozark, MO.

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